Oligonucleotide microarray (DNA chip)–based hybridization analysis is a promising new technology which potentially allows rapid and cost–effective screens for all possible mutations and sequence ...

Phase I Study of Adoptive T-Cell Therapy Using Antigen-Specific CD8+ T Cells for the Treatment of Patients With Metastatic Melanoma Two hundred fifty-one neuroblastoma specimens were analyzed using a ...

For most researchers DNA microarrays are synonymous with high-throughput gene expression analysis. But they also are invaluable genotyping tools. Now that the International HapMap Project (see article ...

Oligonucleotide arrays were utilized to analyze the transcript profiles of 105 bladder tumors: 33 superficial, 72 invasive lesions, and 52 normal urothelium. Hierarchical clustering and supervised ...

Microarray synthesis of DNA oligonucleotides costs a fraction of a penny per base. But such methods can’t make pieces longer than about 200 bases. And stitching those oligonucleotide fragments into ...

Chromosome rearrangements are commonly associated with multiple disease states such as cancer and many developmental syndromes, including Down’s syndrome and autism spectrum disorders. The ...

The main steps involved and limitations of microarray analysis will be encountered. Two stages can be distinguished in microarray experiments: a pre-microarray experiment phase (tissue handling) and ...

In releasing its DualChip microarray system, Eppendorf http://www.eppendorf.com of Hamburg, Germany, has blurred the lines between cDNA and oligonucleotide probes ...

Reviewed by Dr. Tomislav Meštrović, MD, Ph.D. The microarray is a very recent development in the field of biotechnology. Scientists are now able to understand the gene functions of any organism by ...

Oligo array-based CGH is also proving to be a valuable tool for detecting and characterizing copy number aberrations in tumor samples, overcoming the limited resolution of conventional cancer ...